Methyl Iodide ResidualMethyl Iodide Residual

Methyl iodide has been highlighted as a potential genotoxic impurity (PGI). A sensitive HS-GC method with ECD was developed and validated for the determination of methyl iodide impurity in Tedizolid phosphate, an active pharmaceutical ingredient. HS-GC method on DB-624,column 60m × 0.53mm, film thickness 3μm, with electron capture detector (ECD) was used. The proposed method was specific, linear, accurate, rugged and precise. The calibration curves showed good linearity over the concentration range of 0.78 μg/g to 11.7 μg/g and the correlation coefficient was 0.997. Method had very low limit of detection (LOD) and limits of quantification (LOQ) are 0.23 μg/g and 0.78 μg/g, respectively, with respect to test concentration. Accuracy was observed within the range 96.0% to 103.2%. This method is a further extended good quality control tool for low level quantitation of methyl iodide impurity in another API, alogliptin benzoate.

Methyl iodide is such a special electrophile, however, that successful alkylations with it cannot usually be used as an indication that alkylations with higher homologs or with more reactive alkylating agents such as allylic or benzylic halides, will necessarily be so rewarding.

Nanjing Chemical Material Corporation. (NCMC), is a professional chemical distributor company, we provide DMC catalyst, monoammonium glycyrrhizinate, methyl Iodide, allyl glycidyl ether, glycolic acid and etc. Want to know more? Please contact us.

Comments

What is GLycolic Acid?

We like to focus on the ingredients of beauty products. But we prefer to touch the product and explore whether it really works. Alpha hydroxy acid is also known as AHA. It includes glycolic acid , lactic acid and citric acid. These products do not meet the needs. Now we analyze the most popular ingredient in the world - glycolic acid. Glycolic acid is a naturally occurring substance that is added to skin care products. It is good for the skin and restores skin elasticity and moisturization. The original state of glycolic acid is a powder composed of colorless crystals. It is tasteless. Let's first understand its benefits and its related products. The Benefits of Glycolic Acid Glycolic acid is very effective for skin treatment because of its high purity. The premise is safe and correct use. Many skin care products contain glycolic acid. Sensitive muscles can also be used. Glycolic acid is non-irritating and it can be used in skin care. Add more glycolic acid to the facial cl

Acetyl Chloride

Features of Acetyl Chloride Product Name: Acetyl chloride Chemical Formula: C2H3ClO Acetyl chloride cas : 75-36-5 Dangerous Grade: 3.2 Technical Data of Acetyl Chloride ITERMS SPECIFICATION Appearance Colourless transparent liquid Assay ≥99.0% Phosphorus content ≤0.02% Package and Storage: 200kg/drum Store in a cool, dry place. Keep container closed when not in use Application /Application Industries: Acetylation reagent Pharmaceuticals Dye Acetyl chloride is a colorless flammable liquid with a pungent odor. It is violently decomposed by water or ethanol. Dissolved in chloroform, ether, benzene, petroleum ether or glacial acetic acid. Acetyl chloride is an irritant and corrosive agent. Contact with the skin can cause burns, and steam can strongly irritate the eyes and mucous membranes. When people inhale 2 ppm, they can feel the stimulating effect. Short-term exposure to higher concentrations of acetyl chloride may cause death or permanent damage. The amount of aquatic live poisoning

Polyether Polyol Manufacturing ProcessPolyether Polyol Manufacturing Process

Synthesis of DMC-based polyether polyol by a continuous method A certain amount of DMC catalyst is taken and uniformly dispersed in a certain amount of small molecule initiator. Add 0.5 kg of the mixture of the initiator in the small test reactor. The vacuum was replaced 1-2 times with N2, and the N2 pressure was maintained at 0.1 MPa. After heating, stirring and raising the temperature to a certain temperature, the quantitative PO was introduced into the continuous autoclave with nitrogen gas for induction. When the induction is successful (the temperature in the kettle rises and the pressure drops), the PO is continuously passed to carry out the reaction. Open the outer loop and continue to pass the PO into the continuous kettle. When the liquid in the reaction vessel is full, the PO, DMC catalyst and the initiator are continuously added to the kettle at a certain ratio and a certain speed through the power system. Continuous discharge is started when a certain pressure is reac

Nanjing Chemical Material Corp.

Search This Blog