Production and Function of Monoammonium Glycyrrhizinate

Monoammonium glycyrrhizinate in China is a chemical substance. This product is mainly used for the treatment of chronic persistent hepatitis, chronic active hepatitis, liver poisoning, and early liver cirrhosis.

Production method

It is obtained by using crude glycyrrhizic acid (content about 50%, weight method) as raw material and acidic ethanol as extractant. 50g crude glycyrrhizic acid was added to 170ml of 95% ethanol acidified with hydrochloric acid (Ph value 3.5 ～ 4.0), and stirred and extracted at 40 ～ 50 ℃ for 4h. After filtration, the filter residue was extracted with 100 ml of ethanol under the same conditions for 3 hours. The extracts were combined, and ammonia water or ammonia gas was added dropwise with stirring to make the Ph of the solution 7.2 to 7.5, and allowed to stand at room temperature for 0.5 h to completely precipitate.

The precipitate is triammonium glycyrrhizinate, which is dispersed into a paste with an appropriate amount of glacial acetic acid. If necessary, heat it slightly, let it stand for 1h and then filter to convert it into monoammonium salt. After crystal separation, wash with a small amount of glacial acetic acid 1 to 2 times to obtain a pale yellow crude product. Activated carbon was decolorized and recrystallized with 75% ethanol to obtain 15.5 g of white crystals with a yield of 61% and a purity of ≥98%.

The use of monoammonium glycyrrhizinate: it is used in the pharmaceutical industry for cough and phlegm treatment, liver disease treatment, etc.

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